[Pediatric tumors with spindle cell morphology]

Spindle cell tumors in childhood are rare lesions with a heterogeneous morphological picture and clinical course, ranging from benign lesions to fully malignant tumors. The clinical assessment of these tumors is often challenging since some of them show fast growth dynamics but are utterly benign, while a subset of slow-growing tumors can represent malignant entities. Due to the rarity of these tumors as well as the overlapping morphology and the often uncharacteristic immunohistochemical profiles, the pathologic diagnosis is often also difficult. This review gives an overview of some of the more common pediatric spindle cell tumors. In addition to the morphological features and immunohistochemical aspects, specific molecular changes are discussed. Here, some of the newly described translocations that may imply therapeutic options, are presented.