Myoepithelial carcinoma with rhabdoid features in the maxillary sinus: Immunohistochemical and in situ hybridization analysis of a rare case

Heitor Albergoni Silveira; Luciana Yamamoto Almeida; Cassiano Francisco Weege Nonaka; Pollianna Muniz Alves; Alfredo Ribeiro-Silva; Jorge Esquiche León

doi:10.1016/j.oraloncology.2019.04.015

Myoepithelial carcinoma with rhabdoid features in the maxillary sinus: Immunohistochemical and in situ hybridization analysis of a rare case

Oral Oncol. 2019 Jun:93:116-119. doi: 10.1016/j.oraloncology.2019.04.015. Epub 2019 Apr 30.

Authors

Heitor Albergoni Silveira¹, Luciana Yamamoto Almeida², Cassiano Francisco Weege Nonaka³, Pollianna Muniz Alves³, Alfredo Ribeiro-Silva⁴, Jorge Esquiche León⁵

Affiliations

¹ Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (Unesp), Araraquara, São Paulo, Brazil; Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, SP, Brazil.
² Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (Unesp), Araraquara, São Paulo, Brazil. Electronic address: [email protected].
³ Department of Dentistry, State University of Paraíba, Campina Grande, Paraíba, Brazil.
⁴ Department of Pathology and Forensic Medicine, Ribeirão Preto Medical School (FMRP/USP), University of São Paulo, Ribeirão Preto, SP, Brazil.
⁵ Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, SP, Brazil.

PMID: 31053364
DOI: 10.1016/j.oraloncology.2019.04.015

Abstract

Myoepithelial carcinomas of the head and neck are often located in the major salivary glands, notably in the parotid glands, being less frequent in the minor salivary glands. Noteworthy, myoepithelial carcinoma in the maxillary sinus is extremely rare. In fact, only five cases have been previously published to date. Here, we present, for the first time, a detailed immunohistochemical and in situ hybridization analysis of a SMARCB1 (INI-1)-intact myoepithelial carcinoma with rhabdoid features, expanding the histopathological spectrum of high-grade sinonasal carcinomas.

Keywords: Immunohistochemistry; In situ hybridization; Maxillary sinus; Myoepithelial carcinoma; Rhabdoid phenotype; Sinonasal carcinoma.

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Biomarkers, Tumor / metabolism
Humans
In Situ Hybridization
Male
Maxillary Sinus Neoplasms / metabolism*
Myoepithelioma / metabolism*
Rhabdoid Tumor / metabolism*
SMARCB1 Protein / metabolism*

Substances

Biomarkers, Tumor
SMARCB1 Protein
SMARCB1 protein, human