Latent stem cell-stimulating therapy for regeneration of chronic tympanic membrane perforations using IGFBP2-releasing chitosan patch scaffolds

Hoon Seonwoo; Seung Won Kim; Beomyong Shin; Kyoung-Je Jang; Myungchul Lee; Oak-Sung Choo; Mi-Jin Choi; Jangho Kim; Ki-Taek Lim; Jeong Hun Jang; Jong Hoon Chung; Yun-Hoon Choung

doi:10.1177/0885328219845082

Latent stem cell-stimulating therapy for regeneration of chronic tympanic membrane perforations using IGFBP2-releasing chitosan patch scaffolds

J Biomater Appl. 2019 Aug;34(2):198-207. doi: 10.1177/0885328219845082. Epub 2019 May 6.

Authors

Hoon Seonwoo¹, Seung Won Kim², Beomyong Shin³, Kyoung-Je Jang⁴, Myungchul Lee⁴, Oak-Sung Choo^{5

6}, Mi-Jin Choi³, Jangho Kim⁷, Ki-Taek Lim⁸, Jeong Hun Jang⁵, Jong Hoon Chung^{4

9}, Yun-Hoon Choung^{3

5

6}

Affiliations

¹ 1 Department of Industrial Machinery Engineering, College of Life Sciences and Natural Resources, Sunchon National University, Suncheon, Republic of Korea.
² 2 Department of Burns and Plastic Surgery, Affiliated Hospital of Yanbian University, Yanji, Jilin, P. R. China.
³ 3 Department of Biomedical Sciences, BK21 Plus Research Center for Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Republic of Korea.
⁴ 4 Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, Republic of Korea.
⁵ 5 Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of Korea.
⁶ 6 Department of Medical Sciences, Ajou University Graduate School of Medicine, Suwon, Republic of Korea.
⁷ 7 Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju, Republic of Korea.
⁸ 8 Department of Biosystems Engineering, College of Agricultural and Life Sciences, Kangwon National University, Chuncheon, Republic of Korea.
⁹ 9 Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.

PMID: 31060420
DOI: 10.1177/0885328219845082

No abstract available

Keywords: Chronic tympanic membrane perforation; insulin-like growth factor-binding protein 2; latent stem cells; stem cell therapy; tissue engineering.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biomechanical Phenomena
Chitosan / chemistry*
Drug Carriers / chemistry*
Drug Liberation
Female
Humans
Insulin-Like Growth Factor Binding Protein 2 / metabolism*
Rats
Rats, Sprague-Dawley
Regeneration / drug effects
Stem Cell Transplantation
Stem Cells / drug effects
Tissue Engineering
Tissue Scaffolds / chemistry*
Tympanic Membrane / surgery
Tympanic Membrane Perforation / therapy*
Wound Healing / drug effects

Substances

Drug Carriers
Insulin-Like Growth Factor Binding Protein 2
Chitosan