Rh(III)-Catalyzed Hydroarylation of Alkyne MIDA Boronates via C-H Activation of Indole Derivatives

J Org Chem. 2019 Jun 7;84(11):6840-6850. doi: 10.1021/acs.joc.9b00638. Epub 2019 May 23.

Abstract

An efficient approach to trans-indolylvinylboronate derivatives has been developed using an Rh-catalyzed hydroarylation of alkyne N-methyliminodiacetic acid boronates via C-H activation. This protocol constitutes a straightforward route for the synthesis of B-containing aza-heterocycles in good yields with excellent functional group tolerance.

Publication types

  • Research Support, Non-U.S. Gov't