Virology: Poxins Soothe the STING

Alexiane Decout; Andrea Ablasser

doi:10.1016/j.cub.2019.03.031

Virology: Poxins Soothe the STING

Curr Biol. 2019 May 6;29(9):R332-R334. doi: 10.1016/j.cub.2019.03.031.

Authors

Alexiane Decout¹, Andrea Ablasser²

Affiliations

¹ Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
² Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Electronic address: [email protected].

PMID: 31063727
DOI: 10.1016/j.cub.2019.03.031

Abstract

The mammalian cyclic dinucleotide 2',3'-cGAMP is a potent inducer of innate immune responses produced upon detection of cytosolic DNA by cGAS. The mechanisms underlying the control of intracellular cGAMP levels remained unclear. In a new study, Eaglesham et al. identified poxins as 2',3'-cGAMP-specific nucleases allowing immune evasion by viruses.

Publication types

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MeSH terms

Animals
Immunity, Innate
Membrane Proteins*
Nucleotides, Cyclic*
Nucleotidyltransferases
Signal Transduction

Substances

Membrane Proteins
Nucleotides, Cyclic
cyclic guanosine monophosphate-adenosine monophosphate
Nucleotidyltransferases