Abstract
We developed a spermine-conjugated lipophilic Pt(iv) prodrug that is able to reduce the cancer stem cell population in ovarian cancer. The therapeutic effect is attributed to the hydrophobic tail and cationic spermine head group, the combination of which allows the Pt(iv) prodrug to localize in mitochondria and induce corresponding damage.
MeSH terms
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Female
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Flow Cytometry
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Humans
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Hydrophobic and Hydrophilic Interactions
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Neoplastic Stem Cells / drug effects*
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Ovarian Neoplasms / pathology*
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Platinum Compounds / pharmacology*
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Prodrugs / chemistry
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Prodrugs / pharmacology*
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Spectrophotometry, Atomic
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Spermine / chemistry*
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Spermine / pharmacology
Substances
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Antineoplastic Agents
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Platinum Compounds
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Prodrugs
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Spermine