The West coast regional safety pharmacology society meeting update: Filling translational gaps in safety assessment

Najah Abi-Gerges; Carrie McMahon; Hugo Vargas; Philip Sager; Ray Chui; Dale Stevens; Jonathan Davila; Johanna R Schaub; Joseph C Wu; Carlos Del Rio; Chris Mathes; Paul E Miller; Leigh Ann Burns-Naas; Andre Ghetti

doi:10.1016/j.vascn.2019.106582

The West coast regional safety pharmacology society meeting update: Filling translational gaps in safety assessment

J Pharmacol Toxicol Methods. 2019 Jul-Aug:98:106582. doi: 10.1016/j.vascn.2019.106582. Epub 2019 May 9.

Authors

Najah Abi-Gerges¹, Carrie McMahon², Hugo Vargas³, Philip Sager⁴, Ray Chui³, Dale Stevens⁵, Jonathan Davila⁶, Johanna R Schaub⁷, Joseph C Wu⁸, Carlos Del Rio⁹, Chris Mathes¹⁰, Paul E Miller¹⁰, Leigh Ann Burns-Naas², Andre Ghetti¹⁰

Affiliations

¹ AnaBios Corporation, San Diego, CA 92109, USA. Electronic address: [email protected].
² Gilead Sciences, Inc., Foster City, CA 94404, USA.
³ Amgen Inc., Thousand Oaks, CA 92320, USA.
⁴ Stanford University, School of Medicine, Stanford, CA 94305, USA.
⁵ Genentech Inc., South San Francisco, CA 94080, USA.
⁶ NeuCyte Labs, Sunnyvale, CA 94089, USA.
⁷ Pliant Therapeutics, Inc., South San Francisco, CA 94080, USA.
⁸ Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford, CA 94305, USA.
⁹ MyoKardia, Inc., South San Francisco, CA 94080, USA.
¹⁰ AnaBios Corporation, San Diego, CA 92109, USA.

PMID: 31077805
DOI: 10.1016/j.vascn.2019.106582

Abstract

The Safety Pharmacology Society (SPS) held a West Coast Regional Meeting in Foster City, CA on November 14, 2018 at the Gilead Sciences Inc. site. The meeting was attended by scientists from the pharmaceutical and biotechnology industry, contract research organizations (CROs) and academia. A variety of scientific topics were presented by speakers, covering a broad variety of topics in the fields of safety risk assessment; from pro-arrhythmia and contractility risk evaluation, to models of heart failure and seizure in-a-dish; and discovery sciences; from stem cells and precision medicine, to models of inherited cardiomyopathy and precision cut tissue slices. The present review summarizes the highlights of the presentations and provides an overview of the high level of innovation currently underlying many frontiers in safety pharmacology.

Keywords: Drug discovery; Predictivity; Safety pharmacology; Translational science.

Publication types

Review

MeSH terms

Animals
Drug Evaluation, Preclinical / methods
Drug Industry / methods*
Drug-Related Side Effects and Adverse Reactions / prevention & control*
Humans
Pharmacology / methods*
Risk Assessment
Societies, Pharmaceutical