Systemic Dysfunction of Osteoblast Differentiation in Adipose-Derived Stem Cells from Patients with Multiple Myeloma

Véronique Béréziat; Christelle Mazurier; Martine Auclair; Nathalie Ferrand; Séverine Jolly; Tiffany Marie; Ladan Kobari; Indira Toillon; François Delhommeau; Bruno Fève; Annette K Larsen; Michèle Sabbah; Laurent Garderet

doi:10.3390/cells8050441

Systemic Dysfunction of Osteoblast Differentiation in Adipose-Derived Stem Cells from Patients with Multiple Myeloma

Cells. 2019 May 10;8(5):441. doi: 10.3390/cells8050441.

Authors

Véronique Béréziat¹, Christelle Mazurier^{2

3}, Martine Auclair⁴, Nathalie Ferrand⁵, Séverine Jolly^{6

7}, Tiffany Marie^{8

9}, Ladan Kobari¹⁰, Indira Toillon¹¹, François Delhommeau¹², Bruno Fève¹³, Annette K Larsen¹⁴, Michèle Sabbah¹⁵, Laurent Garderet¹⁶

Affiliations

¹ Sorbonne Université, INSERM, UMR_S 938, Centre de Recherche Saint-Antoine-Team Genetic and acquired lipodystrophies, Institut Hospitalo-Universitaire de Cardiométabolisme et Nutrition (ICAN), F-75012 Paris, France. [email protected].
² orbonne Université, INSERM, UMR_S 938, Centre de Recherche Saint-Antoine-Team Proliferation and Differentiation of Stem Cells, Institut Universitaire de Cancérologie, F-75012 Paris, France. [email protected].
³ EFS Ile de France, Unité d'Ingénierie et de Thérapie Cellulaire, Créteil, F-94017 Paris, France. [email protected].
⁴ Sorbonne Université, INSERM, UMR_S 938, Centre de Recherche Saint-Antoine-Team Genetic and acquired lipodystrophies, Institut Hospitalo-Universitaire de Cardiométabolisme et Nutrition (ICAN), F-75012 Paris, France. [email protected].
⁵ Sorbonne Université, INSERM, CNRS, UMR_S 938, Centre de Recherche Saint-Antoine- Team Cancer Biology and Therapeutics, Institut Universitaire de Cancérologie, F-75012 Paris, France. [email protected].
⁶ orbonne Université, INSERM, UMR_S 938, Centre de Recherche Saint-Antoine-Team Proliferation and Differentiation of Stem Cells, Institut Universitaire de Cancérologie, F-75012 Paris, France. [email protected].
⁷ EFS Ile de France, Unité d'Ingénierie et de Thérapie Cellulaire, Créteil, F-94017 Paris, France. [email protected].
⁸ orbonne Université, INSERM, UMR_S 938, Centre de Recherche Saint-Antoine-Team Proliferation and Differentiation of Stem Cells, Institut Universitaire de Cancérologie, F-75012 Paris, France. [email protected].
⁹ EFS Ile de France, Unité d'Ingénierie et de Thérapie Cellulaire, Créteil, F-94017 Paris, France. [email protected].
¹⁰ Sorbonne Université, INSERM, UMR_S 938, Centre de Recherche Saint-Antoine-Team Proliferation and Differentiation of Stem Cells, Institut Universitaire de Cancérologie, F-75012 Paris, France. [email protected].
¹¹ Sorbonne Université, INSERM, UMR_S 938, Centre de Recherche Saint-Antoine-Team Genetic and acquired lipodystrophies, Institut Hospitalo-Universitaire de Cardiométabolisme et Nutrition (ICAN), F-75012 Paris, France. [email protected].
¹² Sorbonne Université, INSERM, UMR_S 938, Centre de Recherche Saint-Antoine-Team Proliferation and Differentiation of Stem Cells, Institut Universitaire de Cancérologie, F-75012 Paris, France. [email protected].
¹³ Sorbonne Université, INSERM, UMR_S 938, Centre de Recherche Saint-Antoine-Team Genetic and acquired lipodystrophies, Institut Hospitalo-Universitaire de Cardiométabolisme et Nutrition (ICAN), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, service d'Endocrinologie, F-75012 Paris, France. [email protected].
¹⁴ Sorbonne Université, INSERM, CNRS, UMR_S 938, Centre de Recherche Saint-Antoine- Team Cancer Biology and Therapeutics, Institut Universitaire de Cancérologie, F-75012 Paris, France. [email protected].
¹⁵ Sorbonne Université, INSERM, CNRS, UMR_S 938, Centre de Recherche Saint-Antoine- Team Cancer Biology and Therapeutics, Institut Universitaire de Cancérologie, F-75012 Paris, France. [email protected].
¹⁶ Sorbonne Université, INSERM, UMR_S 938, Centre de Recherche Saint-Antoine-Team Proliferation and Differentiation of Stem Cells, Assistance Publique-Hôpitaux de Paris, Hôpital Saint Antoine, Département d'Hématologie et de Thérapie Cellulaire, F-75012 Paris, France. [email protected].

Abstract

Keywords: multiple myeloma; bone disease; osteogenesis; adipogenesis; adipose-derived stem cells; bone marrow; senescence; Dickkopf-related protein 1; systemic disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Cell Differentiation
Cells, Cultured
Cellular Senescence
Humans
Intercellular Signaling Peptides and Proteins / metabolism*
Mesenchymal Stem Cells / metabolism*
Mesenchymal Stem Cells / pathology
Middle Aged
Multiple Myeloma / metabolism*
Osteoblasts / metabolism*
Osteoblasts / pathology
Osteogenesis

Substances

DKK1 protein, human
Intercellular Signaling Peptides and Proteins