Transient neonatal hypothyroidism following a short course of maternal amiodarone therapy

J Pediatr Endocrinol Metab. 2019 Jun 26;32(6):631-633. doi: 10.1515/jpem-2018-0553.

Abstract

Background Amiodarone is an iodine-rich medication used to treat maternal and fetal arrhythmias, with known effects on thyroid hormone homeostasis. Case presentation We describe a case of transient neonatal hypothyroidism following a short prenatal course of maternal amiodarone therapy resulting in neonatal TSH elevations exceeding those reported in the available literature.

Keywords: amiodarone; fetal supraventricular tachycardia; hypothyroidism.

Publication types

  • Case Reports

MeSH terms

  • Amiodarone / adverse effects
  • Anti-Arrhythmia Agents / adverse effects*
  • Arrhythmias, Cardiac / drug therapy*
  • Female
  • Humans
  • Hypothyroidism / chemically induced*
  • Hypothyroidism / drug therapy
  • Infant, Newborn
  • Infant, Newborn, Diseases / chemically induced*
  • Infant, Newborn, Diseases / drug therapy
  • Male
  • Maternal Exposure / adverse effects*
  • Prognosis
  • Thyroxine / administration & dosage

Substances

  • Anti-Arrhythmia Agents
  • Amiodarone
  • Thyroxine