Organocatalyzed Rearrangement of S-(2-Oxoalkyl)-thioenoates

J Org Chem. 2019 Jun 7;84(11):7523-7531. doi: 10.1021/acs.joc.9b00925. Epub 2019 May 17.

Abstract

The highly Lewis basic amidine-based catalyst DHIP promotes the rearrangement of S-phenacyl thiocinnamate and related thioesters into dihydrothiophene derivatives. In contrast to previously explored rearrangements of thioesters, the reaction proceeds via a novel Dieckmann-like cyclization pathway. An alternative two-component synthesis of the same products has also been developed.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.