Venous Gas Embolism during Hysteroscopic Endometrial Ablation: Report of 5 Cases and Review of the Literature

J Minim Invasive Gynecol. 2020 Mar-Apr;27(3):748-754. doi: 10.1016/j.jmig.2019.05.003. Epub 2019 May 14.

Abstract

Study objective: To highlight the circumstances, presentation, and treatment of venous gas embolism (VGE) and provide guidance and propose potential changes in surgical practice and perioperative monitoring to minimize the adverse consequences and sequalae of this potentially serious complication.

Design: A case series.

Setting: A university-affiliated teaching hospital.

Patients: Five women developed VGE during hysteroscopic endometrial ablation.

Interventions: From 1990 through 2014, the principle author (G.A.V.) performed 5249 primary and 458 repeat hysteroscopic endometrial ablations under general anesthesia using a monopolar 26F (9-mm) resectoscope connected to a peristaltic pump-driven active inflow and outflow irrigation and distension system (1.5% glycine) and an 8-mm monopolar loop electrode at a 120-W continuous (cut) and/or a 3- to 5-mm rollerball interrupted (coagulation) waveform or a combination of them.

Measurements and main results: Among 5707 procedures, we encountered 5 (0.09%, 1/1140) incidents of VGE during primary ablations. All patients exhibited the same symptoms of ventilatory and hemodynamic decompensation, beginning with a reduction in end-tidal carbon dioxide and arterial oxygen desaturation. All patients recovered after immediate cessation of the surgery and resuscitation including ventilatory support with 100% O2 and intravenous fluids.

Conclusions: Although entrainment of some air/gas bubbles is common during hysteroscopy, life-threatening/fatal VGE is rare (1/1140 cases). Situational awareness and strict adherence to certain principles including understanding the conditions, prerequisites, and pathophysiology of VGE; attention to surgical principles and operative technique; close communication with the anesthesiologist; and early therapeutic intervention are of paramount importance to avoid this rare but potentially serious complication.

Keywords: Abnormal uterine bleeding; Endometrial ablation; Hysteroscopy; Venous gas embolism.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Carbon Dioxide
  • Embolism, Air / diagnosis
  • Embolism, Air / etiology*
  • Endometrial Ablation Techniques / adverse effects*
  • Endometrial Ablation Techniques / methods
  • Female
  • Humans
  • Hysteroscopy / adverse effects*
  • Hysteroscopy / methods
  • Leiomyoma / pathology
  • Leiomyoma / surgery
  • Middle Aged
  • Postoperative Complications / diagnosis
  • Postoperative Complications / etiology
  • Uterine Myomectomy / adverse effects*
  • Uterine Myomectomy / methods
  • Uterine Neoplasms / pathology
  • Uterine Neoplasms / surgery
  • Vascular Diseases / diagnosis
  • Vascular Diseases / etiology
  • Veins / pathology

Substances

  • Carbon Dioxide