Arahyside A, a new norsesquiterpene from Arachis hypogaea

Nat Prod Res. 2020 Nov;34(21):3145-3148. doi: 10.1080/14786419.2019.1607860. Epub 2019 May 21.

Abstract

Six compounds were isolated from the stems and leaves of Arachis hypogaea, including a new norsesquiterpene, arahyside A (1), and five known compounds, 4-(2-methoxyethyl)benzene-1,2-diol (2), (1(R,S),2(R,S))-1-phenylpropane-1,2-diol (3), tachioside (4), 1,3-benzenediol (5), demethylmedicarpin (6). Extensive spectroscopic methods, containing HR-EI-MS, NMR and ECD were used for structural elucidation of this new compound 1. Furthermore, its cytotoxicity was evaluated by MTT assay.

Keywords: Arachis hypogaea; arahyside A; cytotoxic activity; norsesquiterpene.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Arachis / chemistry*
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / pharmacology

Substances

  • Antineoplastic Agents, Phytogenic
  • Sesquiterpenes