DNA methylation is a significant epigenetic modification mode, which plays an important role in embryo reprogramming, stem cell differentiation and tumor occurrence. The ten-eleven translocation (TET) enzyme is a crucial demethylation enzyme, which can catalyze 5-methylcytosine(5mC) to 5-hydroxymethylcytosine(5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine(5caC). These bases represent the epigenetic modifications of DNA and regulate the process of DNA methylation. Understanding the role of TET enzyme in regulating the DNA methylation modification and gene expression can help us to gain the knowledge for the normal growth development and epigenetic regulation in human diseases.
DNA甲基化是一种重要的表观遗传学修饰，在胚胎重编程、干细胞分化和肿瘤的发生中发挥调控作用。TET(ten-eleven translocation)酶为关键的去甲基化酶，可连续将 5-甲基胞嘧啶(5-methylcytosine，5mC)氧化为 5-羟甲基胞嘧啶(5-hydro-xymethylcytosine，5hmC)、5-甲酰胞嘧啶(5-formylcytosine，5fC)和 5-羧基胞嘧啶(5-carboxylcytosine，5caC)，这些碱基代表DNA的表观遗传修饰状态，同时调控DNA去甲基化的进程。研究TET蛋白如何调控DNA甲基化修饰和基因的表达有助于我们深入了解正常的生长发育和人类疾病的表观调控。.