Abstract
Chemical investigation of an EtOH extract of the twigs and leaves of Croton damayeshu afforded 10 new tigliane diterpenoids, crodamoids A-J (1-10), along with five known compounds. Their structures were elucidated by physical data analysis. Compounds 8, 9, and 15 displayed cytotoxic effects against two human tumor cell lines, A549 and HL-60 (IC50: 0.9-2.4 μM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line, Tumor
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Croton / chemistry*
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Croton / toxicity
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Diterpenes / toxicity
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HL-60 Cells
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Phorbols / chemistry
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Phorbols / toxicity*
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Plant Leaves / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Phorbols