Activity of interferons alpha, beta, and gamma against human immunodeficiency virus replication in vitro

AIDS Res Hum Retroviruses. 1987 Summer;3(2):125-33. doi: 10.1089/aid.1987.3.125.

Abstract

The antiviral activities of various interferon preparations against human immunodeficiency virus (HIV) were evaluated in vitro. Recombinant interferon alpha-A, and beta interferons and leukocyte-derived alpha interferons show similar concentration-dependent antiviral activity. Recombinant and lymphocyte-derived gamma interferons show minimal antiviral activity against HIV replication in normal peripheral blood mononuclear cells, but definite activity against HIV in the H9 lymphocytic and U937 monocyte-macrophage cell lines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cells, Cultured
  • HIV / drug effects*
  • HIV / growth & development
  • Humans
  • In Vitro Techniques
  • Interferon Type I / pharmacology*
  • Interferon-gamma / pharmacology*
  • Macrophages / microbiology
  • Recombinant Proteins / pharmacology
  • T-Lymphocytes / microbiology
  • Virus Replication / drug effects*

Substances

  • Interferon Type I
  • Recombinant Proteins
  • Interferon-gamma