Decreased uric acid levels in the acute phase of Plasmodium vivax malaria

Rev Soc Bras Med Trop. 2019 May 16:52:e20170412. doi: 10.1590/0037-8682-0412-2017.

Abstract

Introduction: Uric acid is one of the compounds associated with the inflammatory process in malaria. It acts as an indicator of cellular damage by activating the immune response and inflammatory process.

Methods: We measured serum concentrations of uric acid in 60 symptomatic patients before and after treatment for malarial infections caused by Plasmodium vivax.

Results: Lower serum concentrations of uric acid were found during the acute phase of P. vivax malaria compared to those in its convalescent phase (p < 0.0001).

Conclusions: Patients in the acute phase of malaria had lower uric acid levels than those in its convalescent phase.

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Antimalarials / therapeutic use*
  • Biomarkers / blood
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Malaria, Vivax / blood*
  • Malaria, Vivax / drug therapy
  • Male
  • Middle Aged
  • Uric Acid / blood*
  • Young Adult

Substances

  • Antimalarials
  • Biomarkers
  • Uric Acid