Use of PROMIS-29® in US Veterans: Diagnostic Concordance and Domain Comparisons with the General Population

J Gen Intern Med. 2019 Aug;34(8):1452-1458. doi: 10.1007/s11606-019-05011-9. Epub 2019 May 29.

Abstract

Background: PROMIS® items have not been widely or systematically used within the Veterans Health Administration (VA).

Objective: To examine the concordance of PROMIS-29® scores and medical record diagnosis in US Veterans and to compare Veteran scores relative to US population norms.

Design/participants: Cross-sectional multi-site survey of Veterans (n = 3221) provided sociodemographic and PROMIS-29® domain data. Electronic medical records provided health condition (depression, anxiety, sleep disorders, pain disorders) diagnosis data.

Main measures: For each domain, we calculated PROMIS® standardized T scores and used t tests to compare PROMIS® scores for Veterans diagnosed with each targeted health condition vs. those without that documented clinical diagnosis and compare mean Veterans' PROMIS-29® with US adult population norms.

Key results: Veterans with (vs. without) a depression diagnosis reported significantly higher PROMIS® depression scores (60.3 vs. 49.6, p < .0001); those with an anxiety diagnosis (vs. without) reported higher average PROMIS® anxiety scores (62.7 vs. 50.9, p < .0001). Veterans with (vs. without) a pain disorder reported higher pain interference (65.3 vs. 57.7, p < .0001) and pain intensity (6.4 vs. 4.4, p < .0001). Veterans with (vs. without) a sleep disorder reported higher sleep disturbance (55.8 vs. 51.2, p < .0001) and fatigue (57.5 vs. 51.8, p < .0001) PROMIS® scores. Compared with the general population norms, Veterans scored worse across all PROMIS-29® domains.

Conclusions: We found that PROMIS-29® domains are selectively sensitive to expected differences between clinically-defined groups, suggesting their appropriateness as indicators of condition symptomology among Veterans. Notably, Veterans scored worse across all PROMIS-29(R) domains compared with population norms. Taken collectively, our findings suggest that PROMIS-29® may be a useful tool for VA providers to assess patient's physical and mental health, and because PROMIS® items are normed to the general population, this offers a way to compare the health of Veterans with the adult population at large and identify disparate areas for intervention.

Keywords: PROMIS; Veterans; health-related quality of life; mental health; patient-reported outcomes; physical health; social role.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anxiety / diagnosis
  • Anxiety / epidemiology
  • Anxiety / psychology
  • Cohort Studies
  • Cross-Sectional Studies
  • Depression / diagnosis
  • Depression / epidemiology
  • Depression / psychology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pain / diagnosis
  • Pain / epidemiology
  • Pain / psychology
  • Population Surveillance* / methods
  • Sleep Wake Disorders / diagnosis
  • Sleep Wake Disorders / epidemiology
  • Sleep Wake Disorders / psychology
  • Surveys and Questionnaires / standards*
  • United States / epidemiology
  • Veterans Health Services / standards*
  • Veterans Health Services / trends
  • Veterans* / psychology
  • Young Adult