Osteoporosis and Psoriasis

Actas Dermosifiliogr (Engl Ed). 2019 Oct;110(8):642-652. doi: 10.1016/j.ad.2019.02.005. Epub 2019 May 28.
[Article in English, Spanish]

Abstract

Psoriasis is a chronic inflammatory disease associated with multiple comorbidities, particularly in patients with arthritis or more severe forms of the disease. The link between all these comorbidities is probably systemic inflammation. Several recent studies have indicated that patients with psoriasis may be at an increased risk of pathologic fractures and osteoporosis. Current guidelines on comorbidities in psoriasis do not recommend assessment of bone health. In this article, we review the available evidence on the association between psoriasis and osteoporosis. We first examine the concept of osteoporosis and the role of vitaminD in bone health and then propose an algorithm for managing and treating this condition in patients with psoriasis.

Keywords: Comorbidity; Comorbilidad; Fracturas patológicas; Osteopenia; Osteoporosis; Pathologic fractures; Psoriasis; Vitamin D; Vitamina D.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / adverse effects
  • Bone Density / drug effects
  • Bone and Bones / physiology
  • Densitometry / methods
  • Female
  • Fractures, Spontaneous / etiology
  • Fractures, Spontaneous / prevention & control
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Male
  • Methotrexate / adverse effects
  • Osteoporosis / diagnostic imaging
  • Osteoporosis / etiology*
  • Osteoporosis / therapy
  • Psoriasis / complications*
  • Psoriasis / drug therapy
  • Risk Factors
  • Vitamin D / physiology*

Substances

  • Adrenal Cortex Hormones
  • Immunosuppressive Agents
  • Vitamin D
  • Methotrexate