To explore the clinical significance of C1q tumor necrosis factor-related protein-9 (CTRP9) in patients with cerebral infarction. Our data showed that the serum CTRP9 was significantly lower than that of control group, especially in patients with large artery atherosclerotic cerebral infarction. CTRP9 was first decreased and even lower from day 4 to day 10, then gradually elevated. Logistic regression analysis suggested that high CTRP9 level was a protective factor for cerebral infarction. Thus, CTRP9 could be a factor for further classification of cerebral infarction and provides a potential option for disease prevention and treatment.
本研究旨在探讨CTRP9在脑梗死发生发展过程中的变化及其意义。结果表明，脑梗死组CTRP9水平低于对照组，尤其在大动脉粥样硬化亚组下降更明显；病程中CTRP9先下降后回升，在病程第4天至第10天降低明显，对脑梗死的诊断及分型、病程分期具有参考价值。Logistics回归分析提示高水平CTRP9为脑梗死的保护性因素，对脑梗死的防治提供了新的研究方向。.
Keywords: C1q tumor necrosis factor-related protein-9; Cerebral infarction; Stages; TOAST subtypes.