Metabolic Adaptation Sets the Fate of Regulatory Macrophages

Jorge Domínguez-Andrés; Mihai G Netea

doi:10.1016/j.cmet.2019.05.012

Metabolic Adaptation Sets the Fate of Regulatory Macrophages

Cell Metab. 2019 Jun 4;29(6):1240-1242. doi: 10.1016/j.cmet.2019.05.012.

Authors

Jorge Domínguez-Andrés¹, Mihai G Netea²

Affiliations

¹ Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 8, 6525GA Nijmegen, the Netherlands; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands. Electronic address: [email protected].
² Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 8, 6525GA Nijmegen, the Netherlands; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany. Electronic address: [email protected].

PMID: 31167120
DOI: 10.1016/j.cmet.2019.05.012

Abstract

In this issue of Cell Metabolism, Du et al. (2019) describe how insulin-like growth factor 2 (IGF-2), a protein with structural similarity to insulin, induces an anti-inflammatory phenotype in maturing macrophages through reprogramming of their mitochondrial metabolism. These anti-inflammatory properties are maintained upon secondary stimulation and alleviate experimental autoimmune encephalomyelitis (EAE) in vivo.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Anti-Inflammatory Agents
Encephalomyelitis, Autoimmune, Experimental*
Insulin-Like Growth Factor II*
Macrophages
Oxidative Phosphorylation

Substances

Anti-Inflammatory Agents
Insulin-Like Growth Factor II