Abstract
A pH-sensitive near-infrared fluorescent probe with alkaline pKa, AlkaP-1, was developed by incorporating a benzoyl hydrazine group into a cyanine dye. The significant fluorescence changes in the alkaline regions enable the probe to monitor the alkalization process from acute wounds to chronic wounds in diabetic mice.
MeSH terms
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Animals
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Carbocyanines / chemistry
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Cell Line, Tumor
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Chronic Disease
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Diabetes Mellitus, Experimental / metabolism
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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Humans
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Hydrazines / chemistry
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Hydrogen-Ion Concentration
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Infrared Rays
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Mice, Transgenic
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Optical Imaging
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Wounds and Injuries / diagnosis*
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Wounds and Injuries / metabolism
Substances
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Carbocyanines
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Fluorescent Dyes
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Hydrazines