Inhibition of muscular amino acid release by lipid infusion in man

Eur J Clin Invest. 1987 Aug;17(4):301-5. doi: 10.1111/j.1365-2362.1987.tb02191.x.

Abstract

Amino acid balances of healthy postabsorptive volunteers were investigated with the forearm technique under the influence of an intravenous infusion of triglyceride emulsions (LCT; MCT/LCT) [corrected]. A decrease of the basal muscular release of most of the amino acids, respectively an increase of pre-existent uptake rates [corrected]. In parallel, arterial concentrations of these amino acids declined. With constant insulin levels and substantially unchanged blood glucose levels, this inhibition of muscular proteolysis and/or stimulation of proteosynthesis is most probably due to the increased level of free fatty acids.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Amino Acids / blood
  • Amino Acids / metabolism*
  • Blood Glucose / metabolism
  • Fat Emulsions, Intravenous / pharmacology*
  • Fatty Acids, Nonesterified / blood
  • Humans
  • Muscles / drug effects*
  • Muscles / metabolism
  • Triglycerides / blood

Substances

  • Amino Acids
  • Blood Glucose
  • Fat Emulsions, Intravenous
  • Fatty Acids, Nonesterified
  • Triglycerides