Resistance Reversed in KatG Mutants of Mycobacterium tuberculosis

Trends Microbiol. 2019 Aug;27(8):655-656. doi: 10.1016/j.tim.2019.05.008. Epub 2019 Jun 6.

Abstract

A peptidomimetic containing a thiazolo ring-fused 2-pyridone (C10) has now been reported to inhibit hypoxia-induced tolerance to isoniazid (INH) in Mycobacterium tuberculosis (Flentie et al., Proc. Natl. Acad. Sci. U. S. A., 2019). The C10 compound could also potentiate the bactericidal activity in aerobically grown bacilli, prevented selection of drug-resistant strains, and reversed INH resistance in katG (catalase-peroxidase) mutants.

Keywords: catalase-peroxidase; drug resistance; isoniazid; katG; respiration; tuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Bacterial Proteins
  • Catalase
  • Drug Resistance, Bacterial
  • Isoniazid*
  • Mycobacterium tuberculosis*

Substances

  • Bacterial Proteins
  • Catalase
  • Isoniazid