Abstract
Synovial fluid and peripheral blood T lymphocytes were examined from 10 patients with rheumatoid arthritis and 2 controls. T lymphocytes from inflammatory fluids were activated as shown by their increased size and expression of class II MHC antigens. Of the T cells, 60% were DR positive, 19% DP positive and 29% DQ positive. More Leu 2a than Leu 3a cells were HLA-DR positive. In contrast, few T cells expressed Tac. We conclude that T cell activation is taking place but is incomplete or "frustrated".
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Arthritis, Rheumatoid / immunology*
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Female
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HLA-D Antigens / immunology*
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HLA-DP Antigens / immunology
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HLA-DQ Antigens / immunology
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HLA-DR Antigens / immunology
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Humans
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Interleukin-2 / immunology*
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Male
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Middle Aged
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Receptors, Antigen, T-Cell / immunology*
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Receptors, Immunologic / immunology*
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Receptors, Interleukin-2
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Synovial Fluid / cytology*
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Synovial Fluid / immunology
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T-Lymphocytes / immunology*
Substances
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HLA-D Antigens
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HLA-DP Antigens
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HLA-DQ Antigens
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HLA-DR Antigens
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Interleukin-2
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Receptors, Antigen, T-Cell
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Receptors, Immunologic
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Receptors, Interleukin-2