T cell-derived blast crisis in chronic myelocytic leukemia

Leukemia. 1987 Mar;1(3):210-2.

Abstract

We describe herein the occurrence of a T cell-derived blast crisis of chronic myelocytic leukemia which presented as a typical T cell leukemia on clinical (thymic mass and high white blood cells) and immunological grounds (T6+ T4+ T8+), with rearranged T cell receptor genes and germ line immunoglobulin genes. A Philadelphia chromosome was detected in all blast cell mitoses. The significance of T cell involvement during the chronic and acute phases of chronic myelocytic leukemia is discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, Differentiation / analysis
  • Blast Crisis / genetics
  • Blast Crisis / immunology
  • Blast Crisis / pathology*
  • Female
  • Genes, Immunoglobulin
  • Humans
  • Immunoglobulin Heavy Chains / genetics
  • Leukemia, Myeloid / genetics
  • Leukemia, Myeloid / immunology
  • Leukemia, Myeloid / pathology*
  • Philadelphia Chromosome
  • Receptors, Antigen, T-Cell / genetics
  • T-Lymphocytes / pathology*

Substances

  • Antigens, Differentiation
  • Immunoglobulin Heavy Chains
  • Receptors, Antigen, T-Cell