Objective: To describe the development of the Chronic Obstructive Pulmonary Disease Morning Symptom Diary (COPD-MSD) Chinese version and to test its reliability and validity. Methods: The COPD-MSD Chinese version was developed by the standard cross-cultural translation principle. A hundred and eight patients with COPD in stable condition from the Second Xiangya Hospital were assessed by interview with COPD-MSD Chinese version, and underwent mMRC, CAT scores and pulmonary function test.The reliability and validity were evaluated by performing correlation analysis.The stages of COPD determined by lung function were compared to observe the value of COPD-MSD Chinese version in determining disease severity. Results: The Cronbach's alpha and retest reliability of the total scale were 0.908 and 0.927, respectively.The explanatory factor analysis was conducted using orthogonal rotation through the maximum variation principle components extraction which revealed the presence of 5 components with eigen values exceeding 1, explaining totally 74.257% of the variance, and the total score of the COPD-MSD Chinese version was significantly correlated with the mMRC and CAT scores (r=0.44 and 0.56,P<0.01), indicating that the scale of the convergence validity was good. The COPD-MSD Chinese version scores varied significantly in patients with different severity of COPD(χ(2)=9.808, P<0.05). Conclusion: The COPD-MSD Chinese version showed good reliability and validity and could be used in clinical assessment of morning symptoms in Chinese COPD patients.
目的： 对慢性阻塞性肺疾病（慢阻肺）晨间症状量表（COPD-MSD）进行汉化，并评价COPD-MSD中文版的信度和效度。 方法： 通过标准跨文化翻译方法汉化COPD-MSD，形成COPD-MSD中文版；并选取至中南大学湘雅二医院呼吸与危重症医学科门诊就诊的稳定期慢阻肺患者108例进行量表调查，同时进行改良版英国医学研究委员会呼吸问卷（mMRC）、慢阻肺患者自我评估测试（CAT）评分及测定肺功能，对结果进行相关性分析，评价COPD-MSD中文版的信度和效度。并根据肺功能分级进行COPD-MSD中文版得分比较，观察其对病情严重程度的评估价值。 结果： COPD-MSD中文版标准化后的Cronbach′s α系数为0.908，重测信度为0.927，提示量表具有良好的信度。在效度方面，采用主成分分析法，COPD-MSD中文版按特征值>1的标准通过最大方差正交旋转，共提取出5个主成分，累积方差解释量为74.257%；量表的总分与mMRC和CAT得分明显相关（r值分别为0.44和0.56，均P<0.01)，提示量表的聚合效度良好。病情严重程度不同的4组慢阻肺患者，其COPD-MSD中文版总分组间比较的差异有统计学意义（χ(2)=9.808，P<0.05)。 结论： COPD-MSD中文版具有良好的信度和效度，可以为临床评估我国慢阻肺患者晨间症状提供帮助。.
Keywords: Pulmonary disease, chronic obstructive; Questionnaire; Reliability; Validity.