Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium

Maura Manion; Dimana Dimitrova; Luxin Pei; Juan Gea-Banacloche; Adrian Zelazny; Andrea Lisco; Christa Zerbe; Alexandra F Freeman; Steven M Holland; Christopher G Kanakry; Jennifer A Kanakry; Irini Sereti

doi:10.1093/cid/ciz507

Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium

Clin Infect Dis. 2020 Feb 3;70(4):676-679. doi: 10.1093/cid/ciz507.

Affiliations

¹ National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
² National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
³ Mayo Clinic, Phoenix, Arizona.
⁴ Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland.

Abstract

Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.

Keywords: Mycobacterium avium; bone marrow transplantation; immune reconstitution; primary immunodeficiency.

Published by Oxford University Press for the Infectious Diseases Society of America 2019.

Publication types

Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

MeSH terms

Hematopoietic Stem Cell Transplantation* / adverse effects
Humans
Immune Reconstitution Inflammatory Syndrome*
Mycobacterium Infections*
Mycobacterium avium
Primary Immunodeficiency Diseases*