HIV-1 Envelope FRETted Over by Antibodies

Timothée Bruel; Olivier Schwartz

doi:10.1016/j.chom.2019.05.009

HIV-1 Envelope FRETted Over by Antibodies

Cell Host Microbe. 2019 Jun 12;25(6):767-768. doi: 10.1016/j.chom.2019.05.009.

Authors

Timothée Bruel¹, Olivier Schwartz²

Affiliations

¹ Virus & Immunity Unit, Institut Pasteur, UMR 3569, CNRS, Paris 75015, France; Vaccine Research Institute, Créteil, France. Electronic address: [email protected].
² Virus & Immunity Unit, Institut Pasteur, UMR 3569, CNRS, Paris 75015, France; Vaccine Research Institute, Créteil, France. Electronic address: [email protected].

PMID: 31194935
DOI: 10.1016/j.chom.2019.05.009

Abstract

The HIV-1 Envelope (Env) is a metastable protein that displays several conformational states. In recent works, Lu et al. (2019) in Nature and Alsahafi et al. (2019) in Cell Host & Microbe show that antibodies displaying neutralization or antibody-dependent cellular cytotoxicity (ADCC) target different conformations of the viral glycoprotein.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Antibody-Dependent Cell Cytotoxicity
CD4 Antigens
Glycoproteins
HIV Antibodies
HIV-1 / immunology*

Substances

CD4 Antigens
Glycoproteins
HIV Antibodies