Gene editing based hearing impairment research and therapeutics

Neurosci Lett. 2019 Sep 14:709:134326. doi: 10.1016/j.neulet.2019.134326. Epub 2019 Jun 10.

Abstract

Hearing impairment affects 1 in 500 newborns worldwide and nearly one out of three people over the age of 65 (WHO, 2019). Hereditary hearing loss is the most common type of congenital deafness; genetic factors also affect deafness susceptibility. Gene therapies may preserve or restore natural sound perception, and have rescued deafness in multiple hereditary murine models. CRISPR-Cas9 and base editors (BEs) are newly developed gene editing technologies that can facilitate gene studies in the inner ear and provide therapeutic approaches for hearing impairment. Here, we present recent applications of gene editing in the inner ear.

Keywords: Base editing; CRISPR; Gene editing; Gene therapy; Hearing impairment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CRISPR-Cas Systems / genetics*
  • Deafness / genetics*
  • Deafness / therapy*
  • Gene Editing / methods*
  • Gene Editing / trends
  • Genetic Therapy / methods*
  • Genetic Therapy / trends
  • Hearing Loss / genetics
  • Hearing Loss / therapy
  • Humans