Long non-coding and coding RNA profiling using strand-specific RNA-seq in human hypertrophic cardiomyopathy

Xuanyu Liu; Yi Ma; Kunlun Yin; Wenke Li; Wen Chen; Yujing Zhang; Changsheng Zhu; Tianjiao Li; Bianmei Han; Xuewen Liu; Shuiyun Wang; Zhou Zhou

doi:10.1038/s41597-019-0094-6

Long non-coding and coding RNA profiling using strand-specific RNA-seq in human hypertrophic cardiomyopathy

Sci Data. 2019 Jun 13;6(1):90. doi: 10.1038/s41597-019-0094-6.

Authors

Xuanyu Liu¹, Yi Ma¹, Kunlun Yin¹, Wenke Li¹, Wen Chen¹, Yujing Zhang¹, Changsheng Zhu², Tianjiao Li¹, Bianmei Han¹, Xuewen Liu¹, Shuiyun Wang³, Zhou Zhou⁴

Affiliations

¹ Center of Laboratory Medicine, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, Beijing Key Laboratory for Molecular Diagnostics of Cardiovascular Diseases, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
² Departments of Cardiovascular Surgery, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
³ Departments of Cardiovascular Surgery, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China. [email protected].
⁴ Center of Laboratory Medicine, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, Beijing Key Laboratory for Molecular Diagnostics of Cardiovascular Diseases, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China. [email protected].

Abstract

Hypertrophic cardiomyopathy (HCM) represents one of the most common heritable heart diseases. However, the signalling pathways and regulatory networks underlying the pathogenesis of HCM remain largely unknown. Here, we present a strand-specific RNA-seq dataset for both coding and lncRNA profiling in myocardial tissues from 28 HCM patients and 9 healthy donors. This dataset constitutes a valuable resource for the community to examine the dysregulated coding and lncRNA genes in HCM versus normal conditions.

Publication types

Dataset
Research Support, Non-U.S. Gov't

MeSH terms

Cardiomyopathy, Hypertrophic / genetics*
Gene Expression Profiling
Humans
Myocardium* / metabolism
RNA / genetics*
RNA, Long Noncoding / genetics*
Sequence Analysis, RNA

Substances

RNA, Long Noncoding
RNA