Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Siroon Bekkering; Lotte C A Stiekema; Sophie Bernelot Moens; Simone L Verweij; Boris Novakovic; Koen Prange; Miranda Versloot; Jeanine E Roeters van Lennep; Henk Stunnenberg; Menno de Winther; Erik S G Stroes; Leo A B Joosten; Mihai G Netea; Niels P Riksen

doi:10.1016/j.cmet.2019.05.014

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Cell Metab. 2019 Jul 2;30(1):1-2. doi: 10.1016/j.cmet.2019.05.014. Epub 2019 Jun 13.

Affiliations

¹ Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; Department of Vascular Medicine, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands.
² Department of Vascular Medicine, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands.
³ Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, 3052 Victoria, Australia.
⁴ Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands.
⁵ Department of Internal Medicine, Erasmus University Medical Center, 3015GD Rotterdam, the Netherlands.
⁶ Department of Molecular Biology, RIMLS, Radboud University Medical Center, Nijmegen 6525GA, the Netherlands.
⁷ Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands; Institute for Cardiovascular Prevention (IPEK), 80336 Munich, Germany.
⁸ Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; Department of Medical Genetics, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.
⁹ Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
¹⁰ Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands. Electronic address: [email protected].

PMID: 31204280
DOI: 10.1016/j.cmet.2019.05.014

Abstract

Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cardiovascular Diseases / blood
Cardiovascular Diseases / drug therapy
Cardiovascular Diseases / genetics
Cholesterol, LDL / blood
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Hyperlipoproteinemia Type II / blood
Hyperlipoproteinemia Type II / drug therapy
Hyperlipoproteinemia Type II / genetics
Hyperlipoproteinemia Type II / metabolism*
Interleukin 1 Receptor Antagonist Protein / blood
Interleukin-10 / blood
Interleukin-1beta / blood
Interleukin-6 / blood
Mice
Receptors, LDL / blood

Substances

Cholesterol, LDL
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Interleukin 1 Receptor Antagonist Protein
Interleukin-1beta
Interleukin-6
Receptors, LDL
Interleukin-10