c-Myc steers translation in lymphoma

Marie Cargnello; Ivan Topisirovic

doi:10.1084/jem.20190721

c-Myc steers translation in lymphoma

J Exp Med. 2019 Jul 1;216(7):1471-1473. doi: 10.1084/jem.20190721. Epub 2019 Jun 17.

Authors

Marie Cargnello¹, Ivan Topisirovic^{2

3}

Affiliations

¹ Cancer Research Center of Toulouse, Institut National de la Santé et de la Recherche Médicale UMR 1037, University of Toulouse, Toulouse, France [email protected].
² Lady Davis Institute, Sir Mortimor B. Davis Jewish General Hospital, Montreal, Quebec, Canada [email protected].
³ Gerald Bronfman Department of Oncology, Division of Experimental Medicine and Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

Abstract

Members of the MYC family of oncogenes are master regulators of mRNA translation. In this issue of JEM, Singh et al. (https://doi.org/10.1084/jem.20181726) demonstrate that c-Myc governs protein synthesis in lymphoma cells by interfering with SRSF1- and RBM42-mediated suppression of mRNA translation and by altering selection of translation initiation sites.

Publication types

Comment

MeSH terms

Humans
Lymphoma / genetics*
Oncogenes
Protein Biosynthesis*
Protein Processing, Post-Translational
RNA, Messenger

Substances

RNA, Messenger