Subconjunctival bevacizumab and argon laser photocoagulation for preexisting neovascularization following deep lamellar anterior keratoplasty

Indian J Ophthalmol. 2019 Jul;67(7):1193-1194. doi: 10.4103/ijo.IJO_1583_18.

Abstract

We report a rare case of deep anterior lamellar keratoplasty (DALK) neovascularization managed with combination of subconjunctival bevacizumab and argon laser photocoagulation. A 24 year old male underwent Deep anterior lamellar keratoplasty for corneal stromal opacity following presumed viral keratitis. Deep corneal neovascularization was observed postoperatively which was successfully managed using a combination of subconjunctival bevacizumab and argon laser photocoagulation within one week of DALK. The neovascularization resolved by 3 months and at 2 years follow up, patient maintained good visual acuity of 6/12 Snellen's without recurrence of vascularization. A combination of bevacizumab and argon laser may be an effective approach to manage neovascularisation in the immediate postoperative phase (Post DALK) and improve graft survival.

Keywords: Argon laser photocoagulation; corneal neovascularization; corneal scar; deep anterior lamellar keratoplasty; subconjunctival bevacizumab.

Publication types

  • Case Reports

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage
  • Bevacizumab / administration & dosage*
  • Conjunctiva
  • Corneal Neovascularization / etiology
  • Corneal Neovascularization / therapy*
  • Graft Survival
  • Humans
  • Injections
  • Keratitis / surgery*
  • Keratoplasty, Penetrating / adverse effects*
  • Laser Therapy / methods*
  • Lasers, Excimer / therapeutic use*
  • Male
  • Receptors, Vascular Endothelial Growth Factor / antagonists & inhibitors
  • Tomography, Optical Coherence
  • Visual Acuity
  • Young Adult

Substances

  • Angiogenesis Inhibitors
  • Bevacizumab
  • Receptors, Vascular Endothelial Growth Factor