Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord

M C Fournié-Zaluski; S Bourgoin; F Cesselin; M Hamon; D Le Bars; A H Dickenson; B P Roques

Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord

NIDA Res Monogr. 1986:75:454-6.

Authors

M C Fournié-Zaluski¹, S Bourgoin, F Cesselin, M Hamon, D Le Bars, A H Dickenson, B P Roques

Affiliation

¹ Chimie Organique, U 266 INSERM, UA 498 CNRS, Faculté de Pharmacie, Paris, France.

PMID: 3123963

Abstract

Kelatorphan, a mixed inhibitor of "enkephalinases" is used for demonstrating the implication of endogenous enkephalins in nociceptive transmission at the spinal level.

MeSH terms

Analgesics / pharmacology*
Animals
Dipeptides / pharmacology*
Enkephalin, Methionine / physiology*
In Vitro Techniques
Leucine / analogs & derivatives
Leucine / pharmacology
Neurons / physiology
Pain / physiopathology
Rats
Spinal Cord / drug effects
Spinal Cord / physiology*
Thiorphan
Tiopronin / analogs & derivatives
Tiopronin / pharmacology

Substances

Analgesics
Dipeptides
kelatorphan
Enkephalin, Methionine
Thiorphan
Tiopronin
Leucine
ubenimex