Microscopic Colitis Is Characterized by Intestinal Dysbiosis

David M Morgan; Yueming Cao; Kaia Miller; Jessica McGoldrick; Danielle Bellavance; Samantha M Chin; Stefan Halvorsen; Benjamin Maxner; James M Richter; Slim Sassi; Kristin E Burke; Joseph C Yarze; Jonas F Ludvigsson; Kyle Staller; Daniel C Chung; Hamed Khalili

doi:10.1016/j.cgh.2019.06.035

Microscopic Colitis Is Characterized by Intestinal Dysbiosis

Clin Gastroenterol Hepatol. 2020 Apr;18(4):984-986. doi: 10.1016/j.cgh.2019.06.035. Epub 2019 Jun 27.

Authors

David M Morgan¹, Yueming Cao², Kaia Miller², Jessica McGoldrick², Danielle Bellavance³, Samantha M Chin⁴, Stefan Halvorsen⁵, Benjamin Maxner⁶, James M Richter⁷, Slim Sassi⁸, Kristin E Burke⁷, Joseph C Yarze⁷, Jonas F Ludvigsson⁹, Kyle Staller¹⁰, Daniel C Chung⁷, Hamed Khalili¹¹

Affiliations

¹ Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island.
² Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts.
³ Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
⁴ Washington University School of Medicine in St. Louis, St. Louis, Missouri.
⁵ Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts.
⁶ University of Massachusetts Medical School, Worcester, Massachusetts.
⁷ Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
⁸ Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Orthopedics Oncology Service, Massachusetts General Hospital, Boston, Massachusetts.
⁹ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden.
¹⁰ Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Clinical Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
¹¹ Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Clinical Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. Electronic address: [email protected].

PMID: 31254673
DOI: 10.1016/j.cgh.2019.06.035

Abstract

The critical role of the gut microbiome in microscopic colitis (MC) is evident by the observation that fecal diversion is associated with resolution of mucosal inflammation while restoration of fecal stream is associated with recurrence of disease.¹ Characterization of the composition and function of the gut microbiome in MC therefore could provide insights into disease pathogenesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Colitis*
Colitis, Microscopic* / diagnosis
Dysbiosis
Feces
Gastrointestinal Microbiome*
Humans