Circadian Rhythm Sleep-Wake Phase Disorders

Neurol Clin. 2019 Aug;37(3):527-543. doi: 10.1016/j.ncl.2019.04.003. Epub 2019 May 29.

Abstract

This article reviews delayed and advanced sleep-wake phase disorders. Diagnostic procedures include a clinical interview to verify the misalignment of the major nocturnal sleep episode relative to the desired and social-normed timing of sleep, a 3-month or greater duration of the sleep-wake disturbance, and at least a week of sleep diary data consistent with the sleep timing complaint. Treatment options include gradual, daily shifting of the sleep schedule (chronotherapy); shifting circadian phase with properly timed light exposure (phototherapy); or melatonin administration. Future directions are discussed to conclude the article.

Keywords: Chronotherapy; Circadian; Melatonin; Phototherapy; Sleep disorder; Sleep homeostasis.

Publication types

  • Review

MeSH terms

  • Circadian Rhythm / physiology*
  • Humans
  • Melatonin / therapeutic use
  • Phototherapy / methods
  • Sleep Disorders, Circadian Rhythm* / diagnosis
  • Sleep Disorders, Circadian Rhythm* / physiopathology
  • Sleep Disorders, Circadian Rhythm* / therapy

Substances

  • Melatonin