BACH1 Orchestrates Lung Cancer Metastasis

Nicole M Anderson; M Celeste Simon

doi:10.1016/j.cell.2019.06.020

BACH1 Orchestrates Lung Cancer Metastasis

Cell. 2019 Jul 11;178(2):265-267. doi: 10.1016/j.cell.2019.06.020. Epub 2019 Jun 27.

Authors

Nicole M Anderson¹, M Celeste Simon²

Affiliations

¹ Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
² Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: [email protected].

PMID: 31257029
DOI: 10.1016/j.cell.2019.06.020

Abstract

Two studies in this issue position the stabilization of the transcription factor BACH1 as a critical node in the metastasis of lung cancer and propose two new therapeutic approaches for this leading cause of cancer-related deaths (Lignitto et al., 2019; Wiel et al., 2019).

Publication types

Comment

MeSH terms

Basic-Leucine Zipper Transcription Factors
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms*
NF-E2-Related Factor 2*

Substances

BACH1 protein, human
Basic-Leucine Zipper Transcription Factors
NF-E2-Related Factor 2

Grants and funding

R35 CA220483/CA/NCI NIH HHS/United States