Differentiating spontaneous echo contrast, sludge, and thrombus in the left atrial appendage: Can ultrasound enhancing agents help?

Echocardiography. 2019 Jul;36(7):1413-1417. doi: 10.1111/echo.14405. Epub 2019 Jul 1.

Abstract

The accurate identification of thrombus in the left atrial appendage with transesophageal echocardiogram (TEE) in patients with atrial fibrillation (AF) before cardioversion is essential. Most of these patients have some grade of spontaneous echo contrast (SEC). Severe SEC is often called "sludge," and its prognosis and treatment are still controversial. Current guidelines suggest the use of ultrasound enhancing agents (UEAs) when significant SEC is present. However, little is known about the utility of the UEAs in the differentiation between sludge and less severe SEC.

Keywords: atrial fibrillation; echocardiography; left atrial appendage; sludge; spontaneous echo contrast; ultrasound enhancing agents.

MeSH terms

  • Aged
  • Atrial Appendage / diagnostic imaging*
  • Atrial Fibrillation / complications
  • Atrial Flutter / complications
  • Contrast Media / administration & dosage*
  • Coronary Thrombosis / diagnostic imaging*
  • Coronary Thrombosis / etiology
  • Diagnosis, Differential
  • Echocardiography, Transesophageal*
  • Female
  • Fluorocarbons / administration & dosage*
  • Humans
  • Image Enhancement / methods*
  • Male
  • Retrospective Studies

Substances

  • Contrast Media
  • Fluorocarbons
  • perflutren