Nucleoside Analogs with Antiviral Activity against Yellow Fever Virus

Antimicrob Agents Chemother. 2019 Aug 23;63(9):e00889-19. doi: 10.1128/AAC.00889-19. Print 2019 Sep.

Abstract

Yellow fever virus (YFV) is a human Flavivirus reemerging in parts of the world. While a vaccine is available, large outbreaks have recently occurred in Brazil and certain African countries. Development of an effective antiviral against YFV is crucial, as there is no available effective drug against YFV. We have identified several novel nucleoside analogs with potent antiviral activity against YFV with 50% effective concentration (EC50) values between 0.25 and 1 μM with selectivity indices over 100 in culture.

Keywords: Flaviviridae; antiviral agents; nucleoside analogs; yellow fever virus.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Africa
  • Animals
  • Antiviral Agents / therapeutic use*
  • Brazil
  • Cell Line, Tumor
  • Chlorocebus aethiops
  • Humans
  • Molecular Structure
  • Nucleosides / analogs & derivatives*
  • Nucleosides / therapeutic use*
  • Vero Cells
  • Yellow Fever / drug therapy*
  • Yellow Fever / virology
  • Yellow fever virus / drug effects*
  • Yellow fever virus / pathogenicity*

Substances

  • Antiviral Agents
  • Nucleosides