Correlation between Papilledema and Intracranial Hypertension in Crouzon Syndrome: A Case Report and Review of the Literature

Pediatr Neurosurg. 2019;54(4):223-227. doi: 10.1159/000500767. Epub 2019 Jul 3.

Abstract

Crouzon syndrome represents the most common syndromic craniosynostosis. Ocular complications are frequent, including papilledema and optic atrophy, often related to increased intracranial pressure (ICP). However, there is a poor correlation between ICP normalization and resolution of papilledema. We describe the case of a 6-month-old infant who presented with typical phenotypic features of Crouzon syndrome. Pre- and postoperative ICP monitoring was used. Papilledema persisted despite ICP improvement after decompressive craniectomy. Possible causes of papilledema in this syndromic craniosynostosis are discussed in light of the existing literature.

Keywords: Craniosynostosis; Crouzon syndrome; Intracranial hypertension; Papilledema.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Craniofacial Dysostosis / complications*
  • Craniofacial Dysostosis / surgery
  • Craniosynostoses / complications*
  • Craniosynostoses / surgery*
  • Decompression, Surgical
  • Humans
  • Infant
  • Intracranial Hypertension / etiology*
  • Magnetic Resonance Imaging
  • Male
  • Papilledema / etiology*
  • Phenotype
  • Ultrasonography