Abstract
Diphenylalanine (FF), as the smallest unit and core recognition motif of β-amyloid (Aβ), could self-assemble into nanofibers, which induces an early onset of Alzheimer's disease (AD). Green/near-infrared fluorescent BODIPY probes were designed and synthesized to detect FF-assembly, providing unique insights into the chemical and molecular mechanism of Aβ aggregation and drug development for AD.
MeSH terms
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Biosensing Techniques / methods
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Boron Compounds / chemical synthesis
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Boron Compounds / chemistry*
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Dipeptides
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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Nanofibers / chemistry
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Phenylalanine / analogs & derivatives*
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Phenylalanine / analysis
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Phenylalanine / chemistry
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Protein Multimerization
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Boron Compounds
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Dipeptides
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Fluorescent Dyes
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phenylalanylphenylalanine
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Phenylalanine