Abstract
The complete sequence of the rat immunoglobulin gamma 2c heavy chain constant region has been determined by cDNA cloning and by mRNA sequencing. Comparison with other heavy chain genes reveals a high degree of homology (87%) to mouse gamma 3 and suggests that rat and mouse gamma genes separated from a common set of three ancestral genes.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence*
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DNA / isolation & purification
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Genes, Immunoglobulin*
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Immunoglobulin Constant Regions / genetics*
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Immunoglobulin Constant Regions / isolation & purification
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Immunoglobulin G / genetics*
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Immunoglobulin G / isolation & purification
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Immunoglobulin G / physiology
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Immunoglobulin Heavy Chains / genetics*
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Immunoglobulin Heavy Chains / isolation & purification
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Mice
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Molecular Sequence Data
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Rats
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Sequence Homology, Nucleic Acid*
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Species Specificity
Substances
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Immunoglobulin Constant Regions
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Immunoglobulin G
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Immunoglobulin Heavy Chains
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DNA