Conditional Alox12b Knockout: Degradation of the Corneocyte Lipid Envelope in a Mouse Model of Autosomal Recessive Congenital Ichthyoses

J Invest Dermatol. 2020 Jan;140(1):249-253.e6. doi: 10.1016/j.jid.2019.06.134. Epub 2019 Jul 2.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arachidonate 12-Lipoxygenase / genetics*
  • Disease Models, Animal
  • Genes, Recessive
  • Humans
  • Ichthyosis, Lamellar / genetics*
  • Ichthyosis, Lamellar / metabolism
  • Lipid Peroxidation / genetics
  • Mice
  • Mice, Knockout
  • Mutation / genetics
  • Skin / pathology*
  • Skin Physiological Phenomena

Substances

  • ALOX12B protein, human
  • Alox12b protein, mouse
  • Arachidonate 12-Lipoxygenase