Additional Intestinal Mucosal Biopsy Sampling for Research Is Safe During Pediatric Endoscopic Procedures

Clin Gastroenterol Hepatol. 2020 May;18(5):1233-1234. doi: 10.1016/j.cgh.2019.06.040. Epub 2019 Jul 4.

Abstract

Advancing the understanding of inflammatory bowel disease (IBD) pathogenesis has been facilitated by mechanistic studies that require human intestinal tissue. Enrolling pediatric subjects into these studies improves our knowledge of IBD in this underserved population. Given the additional research protections granted to children, institutional review boards (IRBs) must weigh the benefit of obtaining research biopsies against perceived risks. Although obtaining clinical biopsies from children is generally considered safe, there are only limited data on the safety of obtaining research biopsies in children.1-6.

MeSH terms

  • Biopsy
  • Child
  • Colitis*
  • Endoscopy
  • Humans
  • Inflammatory Bowel Diseases*
  • Intestinal Mucosa