Severe T2-high asthma in the biologics era: European experts' opinion

Eur Respir Rev. 2019 Jul 8;28(152):190054. doi: 10.1183/16000617.0054-2019. Print 2019 Jun 30.

Abstract

The European Respiratory Biologics Forum gathered participants from 21 countries in Madrid, Spain, to discuss the management and treatment of severe asthma in the era of biologics. The current insights on the pathophysiology of severe asthma were discussed, as well as the role of respiratory biologics in clinical practice and strategies for eliminating chronic use of oral corticosteroids. The participants also highlighted the key challenges in identifying patients with severe asthma based on phenotypes, biomarkers and treatable traits, and the existing problems in patient referral to specialist care. The monitoring of treatment was debated and the need for a change towards precision medicine and personalised care was emphasised throughout the meeting. This review provides a summary of the discussions and highlights important concerns identified by the participants regarding the current management of severe asthma.

Publication types

  • Consensus Development Conference
  • Review

MeSH terms

  • Anti-Asthmatic Agents / adverse effects
  • Anti-Asthmatic Agents / therapeutic use*
  • Asthma / drug therapy*
  • Asthma / immunology
  • Asthma / physiopathology
  • Biological Products / adverse effects
  • Biological Products / therapeutic use*
  • Consensus
  • Humans
  • Lung / drug effects*
  • Lung / immunology
  • Lung / physiopathology
  • Phenotype
  • Severity of Illness Index
  • Treatment Outcome

Substances

  • Anti-Asthmatic Agents
  • Biological Products