Abstract
Baloxavir showed broad-spectrum in vitro replication inhibition of 4 types of influenza viruses (90% effective concentration range 1.2-98.3 nmol/L); susceptibility pattern was influenza A ˃ B ˃ C ˃ D. This drug also inhibited influenza A viruses of avian and swine origin, including viruses that have pandemic potential and those resistant to neuraminidase inhibitors.
Keywords:
H7N9; United States; avian influenza; baloxavir; baloxavir marboxil; drug susceptibility; highly pathogenic viruses; influenza viruses; pandemic potential; respiratory infections; viruses; zoonoses; zoonotic influenza.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiviral Agents / pharmacology*
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Chickens / virology
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Dibenzothiepins
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Dogs
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Gammainfluenzavirus / drug effects*
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Humans
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Influenza A virus / drug effects*
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Influenza B virus / drug effects*
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Influenza in Birds / drug therapy
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Influenza in Birds / virology
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Influenza, Human / drug therapy
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Influenza, Human / virology
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Madin Darby Canine Kidney Cells / virology
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Microbial Sensitivity Tests
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Morpholines
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Orthomyxoviridae Infections / drug therapy
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Orthomyxoviridae Infections / veterinary
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Orthomyxoviridae Infections / virology
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Oxazines / pharmacology*
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Pyridines / pharmacology*
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Pyridones
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Swine / virology
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Swine Diseases / drug therapy
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Swine Diseases / virology
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Thiepins / pharmacology*
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Thogotovirus / drug effects*
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Triazines / pharmacology*
Substances
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Antiviral Agents
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Dibenzothiepins
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Morpholines
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Oxazines
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Pyridines
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Pyridones
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Thiepins
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Triazines
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baloxavir