Low b-value (50-100) diffusion-weighted images detect significantly more hyperintense liver lesions in children than T2-weighted images

Background: Low b-value (50-100 s/mm²) diffusion-weighted images (low b-value DWI) have been shown to be superior to T2-weighted fast spin echo sequence (T2-W) in detecting liver lesions in adults. There are no such studies assessing this difference in children.

Objective: The purpose of the study was to compare the sensitivity of low b-value DWI images and T2-W images in detecting focal liver lesions in children.

Materials and methods: A retrospective review of liver magnetic resonance imaging (MRI) to assess focal liver lesions in 50 children (22 males, 28 females; age: 2 months to 17 years [mean: 10.9 years]) was performed. Two radiologists reviewed both low b-value DWI and T2-W sequences independently on different occasions to note lesions, the smallest lesion size and the location. A consensus reading of the entire MRI examination and a correlation with follow-up, other imaging modalities and pathology in available cases were used to determine the final number of lesions as a reference standard. The average number of lesions per patient detected by both readers on each sequence was compared with each other and with the reference standard using the signed-rank test. The smallest lesions detected by each sequence were compared using the paired t-test.

Results: One hundred seventy hyperintense lesions were identified on consensus review to serve as the reference standard. The average number of lesions identified by both readers on low b-value DWI was 134 (79%) and on T2-W was 95 (56%). There was excellent interobserver agreement for detection of lesions on low b-value DWI (intraclass correlation coefficient [ICC]=0.96 [0.93-0.98]) and T2-W (ICC=0.85 [0.75-0.91]), with slightly better agreement on low b-value DWI. Both readers identified significantly more number of lesions on low b-value DWI compared to T2-W (Reader 1: P=0.0036, Reader 2: P=0.0001). Compared to the reference standard (mean number of lesions: 3.45), T2-W detected significantly fewer lesions (mean number of lesions: 1.91; P=0.0001) while there was no significant difference in lesion detection on low b-value DWI (mean number of lesions: 2.68; P=0.1527). Low b-value DWI and T2-W were not significantly different in identifying the smallest lesion size (Reader 1: P=0.19, Reader 2: P=0.47).

Conclusion: Low b-value DWI images are more sensitive than T2-W sequences in detecting hyperintense focal liver lesions in children.