One Message, Many Translations: Heterogeneity Revealed with Multicolor Imaging

Lauren A Blake; Bin Wu

doi:10.1016/j.molcel.2019.06.026

One Message, Many Translations: Heterogeneity Revealed with Multicolor Imaging

Mol Cell. 2019 Jul 11;75(1):3-4. doi: 10.1016/j.molcel.2019.06.026.

Authors

Lauren A Blake¹, Bin Wu²

Affiliations

¹ Department of Biophysics and Biophysical Chemistry, The Solomon H. Snyder Department of Neuroscience, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
² Department of Biophysics and Biophysical Chemistry, The Solomon H. Snyder Department of Neuroscience, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: [email protected].

PMID: 31299206
DOI: 10.1016/j.molcel.2019.06.026

Abstract

mRNA translation and its regulation shape the human proteome. Lyon et al. (2019) and Boersma et al. (2019) introduce new orthogonal peptide-tagging systems to study translation in multiple reading frames. Both groups discovered diverse translation behavior of single mRNAs derived from the same genes.

Publication types

Comment

MeSH terms

Frameshifting, Ribosomal*
Humans
Open Reading Frames
Proteome / genetics
RNA*
RNA, Messenger

Substances

Proteome
RNA, Messenger
RNA