Synthesis of Recoded Bacterial Genomes toward Bespoke Biocatalysis

Pablo I Nikel

doi:10.1016/j.tibtech.2019.07.001

Synthesis of Recoded Bacterial Genomes toward Bespoke Biocatalysis

Trends Biotechnol. 2019 Oct;37(10):1036-1038. doi: 10.1016/j.tibtech.2019.07.001. Epub 2019 Jul 13.

Author

Pablo I Nikel¹

Affiliation

¹ The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark. Electronic address: [email protected].

PMID: 31311671
DOI: 10.1016/j.tibtech.2019.07.001

Abstract

Ongoing efforts in synthetic biology aim at constructing (micro)organisms with (pre)defined properties. A recent breakthrough is the chemical synthesis of a recoded Escherichia coli genome by Fredens et al. (Nature, 2019). Besides the conceptual and technological tour de force, the consequences of this unprecedented effort for whole-cell biocatalysis are multifold.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacteria / genetics
Bacteria / metabolism*
Biocatalysis*
Escherichia coli / genetics
Genome, Bacterial*
Metabolic Engineering / methods*