Using deep maxout neural networks to improve the accuracy of function prediction from protein interaction networks

PLoS One. 2019 Jul 23;14(7):e0209958. doi: 10.1371/journal.pone.0209958. eCollection 2019.

Abstract

Protein-protein interaction network data provides valuable information that infers direct links between genes and their biological roles. This information brings a fundamental hypothesis for protein function prediction that interacting proteins tend to have similar functions. With the help of recently-developed network embedding feature generation methods and deep maxout neural networks, it is possible to extract functional representations that encode direct links between protein-protein interactions information and protein function. Our novel method, STRING2GO, successfully adopts deep maxout neural networks to learn functional representations simultaneously encoding both protein-protein interactions and functional predictive information. The experimental results show that STRING2GO outperforms other protein-protein interaction network-based prediction methods and one benchmark method adopted in a recent large scale protein function prediction competition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computational Biology*
  • Humans
  • Neural Networks, Computer*
  • Protein Interaction Mapping*
  • Protein Interaction Maps*
  • Proteins* / genetics
  • Proteins* / metabolism

Substances

  • Proteins